Miconazole Nitrate

CAS number: 22832-87-7

Molecular formula: C18H15Cl4N3O4

molecular weight: 479.14

Chemical structure:

Sr No.TestSpecificationResult
1DescriptionWhite or almost white crystalline powder or micro Crystalline   powderWhite crystalline powder
2SolubilitySparingly soluble in methanol , slightly soluble in ethanol or   chloroform , very slightly soluble in water and in ether .Sparingly soluble in methanol slightly soluble in ethanol or   chloroform, very slightly soluble in water and in ether
3Identification
A) Melting pointIn between 1780C to 1840C1800C
B) Infrared AbsorptionIR spectrum of sample should be concordant with IR spectrum of   standardIR spectrum of sample concordant with IR spectrum of standard
C) HPLCAs per IP should passesTest Passes

D) Test for NitrateGives the reactions of nitratesTest Passes
4Appearance of solution 10% w/v solution in methanolSolution is clear , and not more intensely coloured than reference   solution YS7Test Passes
5Related substances by HPLCAs per USPTest Passes
6Loss on dryingMaximum 0.5 %0.22%
7Sulphated ashMaximum 0.1 %0.03%
8Assay by auto titratorIn between 98.50 % to 101.50 %99.74%